Early infection

In childhood, viral mumps may lead to serious destruction and infection of the ovary in the early stage; in addition, bilateral fallopian tubes and ovarian abscesses may also damage the ovarian tissue and lead to premature failure of the ovary.

Genetic factors

X chromosome deletion or aberrance can cause atrophy and degeneration of the formed follicles. Most of the follicles have degenerated before birth. Occasionally, a small number of non degenerated follicles remain until puberty, and the patient shows secondary amenorrhea.

Immune factors

Premature ovarian failure is often accompanied by thyroiditis, systemic lupus erythematosus, rheumatoid arthritis and other diseases. At this time, there are anti ovarian antibodies in the patient's peripheral blood. The combination of antibodies and corresponding cells in the follicle will damage the follicle and lead to ovarian failure.

Idiopathic premature ovarian failure

The most common type of premature ovarian failure is premature menopause without definite inducement. The karyotype is 46XX, and autoimmune antibodies are usually not detected.

Hypophysis dysfunction

Excessive stimulation of gonadotropin can accelerate follicular atresia, make excessive consumption of follicles, and then induce premature ovarian failure.

Ovarian surgery

Partial ovariectomy, exfoliation of ovarian cyst or removal of one side accessory, radiotherapy, chemotherapy, etc. all of these will affect the ovary and lead to premature ovarian failure.